Article
HIV-1 transmission by dendritic cell-specific ICAM-3-grabbing nonintegrin (DC-SIGN) is regulated by determinants in the carbohydrate recognition domain that are absent in liver/lymph node-SIGN (L-SIGN).
The Journal of biological chemistry - 15 Jan 2010
Chung Nancy P Y, Breun Sabine K J, Bashirova Arman, Baumann Joerg G, Martin Thomas D, Karamchandani Jaideep M, Rausch Jason W, Le Grice Stuart F J, Wu Li, Carrington Mary, Kewalramani Vineet N
Abstract excerpt
In this study, we identify determinants in dendritic cell-specific ICAM-3-grabbing nonintegrin (DC-SIGN) necessary for human immunodeficiency virus, type 1 (HIV-1), transmission. Although human B cell lines expressing DC-SIGN efficiently capture and transmit HIV-1 to susceptible target cells, cel...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.