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Article

Human Sperm-Specific Peptide Vaccine That Causes Long-Term Reversible Contraception1

1 Aug 2002

Abstract excerpt

A novel dodecamer peptide sequence, YLP(12), was identified on human sperm that is involved in oocyte binding. We investigated its immunocontraceptive effects in a murine model. A vaccine was prepared by conjugating the synthetic YLP(12) peptide with the binding subunit of recombinant cholera toxin. Vaccination of female mice by i.m. or intranasal routes without any additional adjuvant induced a sperm-specific...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 12135913
DOI: 10.1095/biolreprod67.2.674

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