Article
Virologic response to nelfinavir-based regimens: pharmacokinetics and drug resistance mutations (VIRAPHAR study).
AIDS (London, England) - 5 Jul 2002
Pellegrin Isabelle, Breilh Dominique, Montestruc François, Caumont Anne, Garrigue Isabelle, Morlat Philippe, Le Camus Cécile, Saux Marie-Claude, Fleury Hervé J A, Pellegrin Jean-Luc
Abstract excerpt
OBJECTIVE: To assess the impact of HIV-1 protease and reverse transcriptase (RT) mutations, and pharmacokinetic parameters on virological responses to nelfinavir (NFV)-containing highly active antiretroviral therapy. DESIGN: Naive or antiretroviral-experienced HIV-1-infected subjects were included in a non-randomized, observational cohort study and received two nucleoside RT inhibitors + NFV (750 mg three times...
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