Article
Mechanisms of early virologic failure in antiretroviral-naive patients starting protease inhibitor-containing regimens: the APROVIR Study.
The Journal of infectious diseases - 15 Nov 2002
Masquelier Bernard, Peytavin Gilles, Leport Catherine, Droz Cecile, Duran Ségolène, Verdon Renaud, Besnier Jean-Marc, Chêne Geneviève, Raffi François, Brun-Vézinet Françoise
Abstract excerpt
The virologic and pharmacologic mechanisms of virologic failure (VF) were studied in 243 antiretroviral-naive patients starting first-line protease inhibitor (PI)-containing therapy (nelfinavir in 66% and indinavir in 19%). Among the 220 patients with follow-up data, VF occurred in 35 (16%) during the first year of follow-up. A higher baseline virus load and poorer adherence to therapy were associated with VF. At...
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