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Article

Lys 43 and Asp 46 in alpha-helix 3 of uteroglobin are essential for its phospholipase A2 inhibitory activity.

Biochemical and biophysical research communications - 26 Jul 2002

Chowdhury Bhabadeb, Mantile-Selvaggi Giuditta, Miele Lucio, Cordella-Miele Eleonora, Zhang Zhongjian, Mukherjee Anil B

Abstract excerpt

Uteroglobin (UG) is an anti-inflammatory, secreted protein with soluble phospholipase A2 (sPLA2)-inhibitory activity. However, the mechanism by which UG inhibits sPLA2 activity is unknown. UG is a homodimer in which each of the 70-amino acid subunits forms four alpha-helices. We previously reported that sPLA2-inhibitory activity of UG may reside in a segment of alpha-helix 3 that is exposed to the solvent. In...

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PMID: 12127976
DOI: 10.1016/s0006-291x(02)00767-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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