Article
Association of the uteroglobin gene polymorphism with IgA nephropathy.
American journal of kidney diseases : the official journal of the National Kidney Foundation - 1 Jan 2002
Matsunaga Akira, Numakura Chikahiko, Kawakami Takako, Itoh Yoshihisa, Kawabata Isao, Masakane Ikuto, Suzuki Takashi, Suzuki Masayuki, Goto Toshikazu, Itoh Kouichi, Hayasaka Kiyoshi
Abstract excerpt
Immunoglobulin A (IgA) nephropathy results from the abnormal deposition of IgA in the renal mesangium. Genetic factors may be involved in the development and progression of IgA nephropathy. Uteroglobin (UG) is a steroid-inducible, cytokine-like, multifunctional protein with anti-inflammatory and immunomodulatory properties. The knockout or antisense mouse of the UG gene develops renal disease similar to IgA...
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