Article
Hb Gunma (beta Gunma) with pulmonary embolism.
Internal medicine (Tokyo, Japan) - 1 May 1995
Iizumi T, Suriki H, Sato F, Harano T
Abstract excerpt
A 67-year-old woman with pulmonary embolism was suspected to have beta-thalassemia based on microcytosis, hemolysis and a negative red cell stability test. The DNA sequencing analysis of beta-globin gene, however, revealed the deletion of three nucleotides within codon 127-128, leading to substitution of glutamine and alanine residues at 127 and 128 by proline, namely Hb Gunma. This mutant is characterized by the...
Topics
- Aged
- Base Sequence
- Female
- Globins
- Hemoglobins, Abnormal
- Humans
- Molecular Sequence Data
- Mutation
- Pulmonary Embolism
- beta-Thalassemia