Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Amino-terminally truncated desmin rescues fusion of des(-/-) myoblasts but negatively affects cardiomyogenesis and smooth muscle development.

FEBS letters - 17 Jul 2002

Höllrigl Alexandra, Puz Sonja, Al-Dubai Haifa, Kim Jai Up, Capetanaki Yassemi, Weitzer Georg

Abstract excerpt

Desmin fulfils important functions in maintenance of muscle cells and mutations in the desmin gene have been linked to a variety of myopathies. To ascertain the role of desmin's amino-terminal domain in muscle cells we generated embryonic stem cells constitutively expressing desmin(Delta1-48) in a null background and investigated muscle cell development in vitro. Desmin(Delta1-48) lacking the first 48 amino acid...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Fusion
Share to Desmin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Muscle Development

Share to Muscle, Smooth

Share to Myocardium

Share to Stem Cells

Share to Vimentin

Source

Identifiers

PMID: 12123837
DOI: 10.1016/s0014-5793(02)02995-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Amino-terminally truncated desmin rescues fusion of des(-/-) myoblasts but negatively affects cardiomyogenesis and smooth muscle development.PMID 12123837Read ↗

Desminopathies: pathology and mechanisms.Semantic proximity Read ↗

Desmin related disease: a matter of cell survival failure.Semantic proximity Read ↗

Molecular insights into cardiomyopathies associated with desmin (DES) mutationsSemantic proximity Read ↗

Desmin-p.L112Q Disturbs the Filament Formation and Is a Likely-Pathogenic Variant Associated with Dilated CardiomyopathySemantic proximity Read ↗

Pathophysiological mechanisms of cardiomyopathies induced by desmin gene variants located in the C-Terminus of segment 2B.Semantic proximity Read ↗

Primary desminopathies.Semantic proximity Read ↗

Cytoskeletal control of myogenesis: a desmin null mutation blocks the myogenic pathway during embryonic stem cell differentiation.Semantic proximity Read ↗

Knockout of zebrafish desmin genes does not cause skeletal muscle degeneration but alters calcium fluxSemantic proximity Read ↗

Generation of a patient-specific induced pluripotent stem cell line carrying the DES p.R406W mutation, an isogenic control and a DES p.R406W knock-in line.Semantic proximity Read ↗

Knockout of zebrafish desmin genes does not cause skeletal muscle degeneration but alters calcium flux.Semantic proximity Read ↗

Desmin myopathy, a skeletal myopathy with cardiomyopathy caused by mutations in the desmin gene.Semantic proximity Read ↗

[Desmin filaments and their disorganization associated with myofibrillar myopathies].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.