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Article

Connexin 43, but not connexin 32, is mutated at advanced stages of human sporadic colon cancer.

Oncogene - 25 Jul 2002

Dubina Michael V, Iatckii Nikolay A, Popov Dimitrii E, Vasil'ev Sergei V, Krutovskikh Vladimir A

Abstract excerpt

The membrane-spanning connexin proteins form microscopic intercellular channels that directly connect the cytoplasms of adjacent cells and as such have been implicated in maintenance of tissue homeostasis. They are considered to act as tumor suppressors since their function or expression is frequently aberrant in tumor cells. Several mechanisms appear to be involved in this, but irreversible mutational...

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Identifiers

PMID: 12118378
DOI: 10.1038/sj.onc.1205630

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Connexin 43, but not connexin 32, is mutated at advanced stages of human sporadic colon cancer.PMID 12118378Read ↗

[The scientific and clinical value of molecular genetic changes in the intercellular gap junctions observed in colon cancer].Semantic proximity Read ↗

RNF43 pathogenic Germline variant in a family with colorectal cancer.Semantic proximity Read ↗

Altered homologous and heterologous gap-junctional intercellular communication in primary human liver tumors associated with aberrant protein localization but not gene mutation of connexin 32.Semantic proximity Read ↗

Background lesions during a 24-month observation period in connexin 32-deficient mice.Semantic proximity Read ↗

Genotype/phenotype correlation in affected individuals of a family with a deletion of the entire coding sequence of the connexin 32 gene.Semantic proximity Read ↗

Involvement of gap junctions in tumor suppression: analysis of genetically-manipulated mice.Semantic proximity Read ↗

Both early and late stages of hepatocarcinogenesis are enhanced in Cx32 dominant negative mutant transgenic rats with disrupted gap junctional intercellular communication.Semantic proximity Read ↗

Deletion and nonsense mutations of the connexin 32 gene associated with Charcot-Marie-Tooth disease.Semantic proximity Read ↗

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