Article
Modulating influence on HIV/AIDS by interacting RANTES gene variants.
Proceedings of the National Academy of Sciences of the United States of America - 23 Jul 2002
An Ping, Nelson George W, Wang Lihua, Donfield Sharyne, Goedert James J, Phair John, Vlahov David, Buchbinder Susan, Farrar William L, Modi William, O'Brien Stephen J, Winkler Cheryl A
Abstract excerpt
RANTES (regulated on activation normal T cell expressed and secreted), a ligand for the CC chemokine receptor 5, potently inhibits HIV-1 replication in vitro. We tested the influence of four RANTES single nucleotide polymorphism (SNP) variants and their haplotypes on HIV-1 infection and AIDS progression in five AIDS cohorts. Three SNPs in the RANTES gene region on chromosome 17 (403A in the promoter, In1.1C in...
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