Article
Frequent germ-line succinate dehydrogenase subunit D gene mutations in patients with apparently sporadic parasympathetic paraganglioma.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jul 2002
Dannenberg Hilde, Dinjens Winand N M, Abbou Mustaffa, Van Urk Hero, Pauw Bernard K H, Mouwen Diane, Mooi Wolter J, de Krijger Ronald R
Abstract excerpt
PURPOSE: Recently, familial paraganglioma (PGL) was shown to be caused bymutations in the gene encoding succinate dehydrogenase subunit D (SDHD). However, the prevalence of SDHD mutations in apparently sporadic PGL is unknown. We studied the frequency and spectrum of germ-line and somatic SDHD mutations in patients with parasympathetic PGL. EXPERIMENTAL DESIGH: We studied 57 unselected patients who developed...
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