Article
The prognostic significance of overexpression of the decoy receptor for Fas ligand (DcR3) in patients with gastric carcinomas.
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association - 1 Jan 2002
Takahama Yasushi, Yamada Yukishige, Emoto Koji, Fujimoto Heisuke, Takayama Tomoyoshi, Ueno Masatoh, Uchida Hideki, Hirao Shuya, Mizuno Takashi, Nakajima Yoshiyuki
Abstract excerpt
BACKGROUND: The FasL-Fas system has an important role in mediating immune-cytotoxic killing of cells such as virus-infected or tumor cells. It was recently reported that there is a soluble decoy receptor (DcR3), which binds to FasL and inhibits FasL-induced apoptosis, and certain tumors may escape FasL-dependent immune-cytotoxic attack by expressing a decoy receptor that blocks FasL. We evaluated whether DcR3 has...
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