Article
Lack of evidence for a significant association between nonsyndromic cleft lip with or without cleft palate and the retinoic acid receptor alpha gene in the Japanese population.
Journal of human genetics - 1 Jan 2002
Kanno Kiyoshi, Suzuki Yoichi, Yang Xuemei, Yamada Atsushi, Aoki Yoko, Kure Shigeo, Matsubara Yoichi
Abstract excerpt
Nonsyndromic cleft lip with or without cleft palate (NSCLP) is one of the most common craniofacial malformations. Both genetic and environmental factors are thought to be involved in the pathogenesis. The retinoic acid receptor alpha ( RARA) is one of the candidate genes for the pathogenesis of NSCLP. An association between a PstI restriction fragment length polymorphism or D17S579 microsatellite marker...
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