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Article

Significant impact of promoter hypermethylation and the 540 C>T polymorphism of CDKN2A in cutaneous melanoma of the vertical growth phase.

The American journal of pathology - 1 Jul 2002

Straume Oddbjørn, Smeds Johanna, Kumar Rajiv, Hemminki Kari, Akslen Lars Andreas

Abstract excerpt

Promoter hypermethylation, mutations, and loss of heterozygosity in the CDKN2A gene as well as polymorphisms at the 3'-untranslated region were determined in vertical growth phase melanomas. Methylation-specific polymerase chain reaction in soluti and in situ showed that 19% of the cases were hypermethylated at the CDKN2A promoter region, and some of these cases were heterogeneous with both methylated and...

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Identifiers

PMID: 12107107
DOI: 10.1016/S0002-9440(10)64174-0
PMCID: PMC1850679

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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