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Article

Remarkably high activities of testicular cytochrome c in destroying reactive oxygen species and in triggering apoptosis

6 Jun 2006

Abstract excerpt

Hydrogen peroxide (H(2)O(2)) is the major reactive oxygen species (ROS) produced in sperm. High concentrations of H(2)O(2) in sperm induce nuclear DNA fragmentation and lipid peroxidation and result in cell death. The respiratory chain of the mitochondrion is one of the most productive ROS generating systems in sperm, and thus the destruction of ROS in mitochondria is critical for the cell. It was recently...

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PMID: 16757556
DOI: 10.1073/pnas.0603327103

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