Histone deacetylases in <i>Trypanosoma brucei</i>: two are essential and another is required for normal cell cycle progression

Abstract excerpt

Reversible protein acetylation is established as a modification of major regulatory significance. In particular, histone acetylation regulates access to genetic information in eukaryotes. For example, class I and class II histone deacetylases are regulatory components of corepressor complexes involved in cell cycle progression and differentiation. Here, we have investigated the function of such enzymes in...

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