Article
[Molecular screening of MC4R gene and association with fat traits in pig resource family].
Yi chuan xue bao = Acta genetica Sinica - 1 Jun 2002
Liu Gui-Lan, Jiang Si-Wen, Xiong Yuan-Zhu, Zheng Rong, Qu Yan-Chun
Abstract excerpt
Melanocortin-4 Receptor (MC4R) plays an important role in the regulation of human obesity. It can cooperate with leptin, neuropeptide Y(NPY) and melanocyte-stimulating hormone (MSH) to regulate body weight and feeding. Inactivation of this receptor by gene targeting in mice results in a maturity onset obesity syndrome associated with hyperphagic, hyperinsulinemia, hyperglycemia, as well as decreased linear growth...
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