Article
Association of a melanocortin 4 receptor (MC4R) polymorphism with performance traits in Lithuanian White pigs.
Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie - 1 Feb 2006
Jokubka R, Maak S, Kerziene S, Swalve H H
Abstract excerpt
The melanocortin 4 receptor is expressed in virtually all brain regions of mammals and plays an important role in energy homeostasis. Polymorphisms in this gene may thus be related to growth and obesity. In pigs, a non-synonymous polymorphic site was described (Asp298Asn) and demonstrated to affect cAMP production and to alter adenylyl cyclase signalling. Association studies revealed significant linkage of this...
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