Article
The glial growth factors deficiency and synaptic destabilization hypothesis of schizophrenia.
BMC psychiatry - 3 Jul 2002
Moises Hans W, Zoega Tomas, Gottesman Irving I
Abstract excerpt
BACKGROUND: A systems approach to understanding the etiology of schizophrenia requires a theory which is able to integrate genetic as well as neurodevelopmental factors. PRESENTATION OF THE HYPOTHESIS: Based on a co-localization of loci approach and a large amount of circumstantial evidence, we here propose that a functional deficiency of glial growth factors and of growth factors produced by glial cells are...
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