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Sperm DNA damage in potentially fertile homozygous -thalassaemia patients with iron overload

1 Jul 2002

Abstract excerpt

BACKGROUND: To test the hypothesis that human sperm DNA could sustain iron-induced oxidative damage and reduce its fertilizing ability, we studied patients with homozygous beta-thalassaemia major (HbTh) as a model of iron overload. METHODS: Sperm from six thalassaemic patients and five age-matched controls were assessed by the sperm chromatin structure assay (SCSA) and terminal deoxynucleotidyl...

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Share to Hemoglobinopathies and Related Disorders
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PMID: 12093845
DOI: 10.1093/humrep/17.7.1820

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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