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Article

The significance of sperm nuclear DNA strand breaks on reproductive outcome

3 May 2005

Abstract excerpt

PURPOSE OF REVIEW: A growing body of evidence indicates that ejaculated spermatozoa from men being treated with intracytoplasmic sperm injection contain nuclear abnormalities. Many of these nuclear anomalies manifest themselves as breaks in the sperm nuclear DNA. This review examines the mechanisms involved in generating DNA strand breaks during spermatogenesis in the human, the main techniques used to assess the...

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PMID: 15870559
DOI: 10.1097/01.gco.0000169102.77504.66

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