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Article

In-vitro effects of FSH and testosterone withdrawal on caspase activation and DNA fragmentation in different cell types of human seminiferous epithelium

1 Jul 2002

Abstract excerpt

BACKGROUND: Caspases are downstream elements of apoptosis-mediating pathways initiated by the Fas ligand/Fas receptor system which is supposed to play a central role in the regulation of apoptosis in the human seminiferous epithelium. However, caspase activity in different cell types of this epithelium has never been addressed. METHODS AND RESULTS: We evaluated caspase activity and DNA integrity in Sertoli and...

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PMID: 12093844
DOI: 10.1093/humrep/17.7.1811

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