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Article

TNFα Down-Regulates the Fas Ligand and Inhibits Germ Cell Apoptosis in the Human Testis

1 Sept 2001

Abstract excerpt

The cytokine TNFalpha is known to be secreted by testicular germ cells. However, its effect on maturing germ cells is unknown, and its role in the regulation of spermatogenesis is unclear. Here we aimed at characterizing the effects of TNFalpha on germ cell survival in the human testis. We found that TNFalpha effectively and dose-dependently inhibited germ cell apoptosis, which was induced in vitro by incubating...

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PMID: 11549697
DOI: 10.1210/jcem.86.9.7861

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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