Article
Overexpression of arginase I in enterocytes of transgenic mice elicits a selective arginine deficiency and affects skin, muscle, and lymphoid development.
The American journal of clinical nutrition - 1 Jul 2002
de Jonge Wouter J, Hallemeesch Marcella M, Kwikkers Karin L, Ruijter Jan M, de Gier-de Vries Corrie, van Roon Marian A, Meijer Alfred J, Marescau Bart, de Deyn Peter P, Deutz Nicolaas E P, Lamers Wouter H
Abstract excerpt
BACKGROUND: Arginine is required for the detoxification of ammonia and the synthesis of proteins, nitric oxide, agmatine, creatine, and polyamines, and it may promote lymphocyte function. In suckling mammals, arginine is synthesized in the enterocytes of the small intestine, but this capacity is lost after weaning. OBJECTIVE: We investigated the significance of intestinal arginine production for neonatal...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.