Article
The SH3, HOOK and guanylate kinase-like domains of hDLG are important for its cytoplasmic localization.
Genes to cells : devoted to molecular & cellular mechanisms - 1 Jul 2002
Kohu Kazuyoshi, Ogawa Fumiaki, Akiyama Tetsu
Abstract excerpt
BACKGROUND: hDLG, the human homologue of the Drosophila tumour suppressor dlg, functions as a scaffolding protein that facilitates the transmission of diverse downstream signals. hDLG possesses multiple protein-binding domains, including three PDZ domains, an SH3 domain, a HOOK domain and a guanylate kinase-like (GK) domain. RESULTS: We studied the significance of the PDZ, SH3, HOOK and GK domains in the...
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