Article
Extensive interbreed, but minimal intrabreed, variation of DLA class II alleles and haplotypes in dogs.
Tissue antigens - 1 Mar 2002
Kennedy Lorna J, Barnes A, Happ G M, Quinnell R J, Bennett D, Angles J M, Day M J, Carmichael N, Innes J F, Isherwood D, Carter S D, Thomson W, Ollier W E R
Abstract excerpt
The DLA class II genes in the dog major histocompatibility complex are highly polymorphic. To date, 52 DLA-DRB1, 16 DLA-DQA1 and 41 DLA-DQB1 allelic sequences have been assigned. The aim of this study was to examine the intrabreed and interbreed variation of DLA allele and haplotype frequencies in dogs, and to ascertain whether conserved DLA class II haplotypes occur within and between different breeds. One...
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