Article
Investigating the association between OPA1 polymorphisms and glaucoma: comparison between normal tension and high tension primary open angle glaucoma.
Human genetics - 1 May 2002
Aung Tin, Ocaka Louise, Ebenezer Neil D, Morris Alex G, Brice Glen, Child Anne H, Hitchings Roger A, Lehmann Ordan J, Bhattacharya Shomi S
Abstract excerpt
OPA1, the gene responsible for autosomal dominant optic atrophy, represents a good candidate gene for glaucoma, as there are similarities in the clinical phenotype and OPA1 is expressed in the optic nerve. Single nucleotide polymorphisms on intervening sequence (IVS) 8 of the OPA1gene (genotype IVS8+4 C/T;+32T/C) were recently found to be strongly associated with normal tension glaucoma (NTG). In order to...
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