Article
The phenotype of normal tension glaucoma patients with and without OPA1 polymorphisms.
The British journal of ophthalmology - 1 Feb 2003
Aung T, Okada K, Poinoosawmy D, Membrey L, Brice G, Child A H, Bhattacharya S S, Lehmann O J, Garway-Heath D F, Hitchings R A
Abstract excerpt
AIM: Polymorphisms in OPA1, the gene responsible for autosomal dominant optic atrophy, were recently found to be strongly associated with normal tension glaucoma (NTG). The aim of this study was to determine whether OPA1 polymorphisms affect the phenotype of NTG patients. METHODS: A retrospective analysis was performed of 108 well characterised NTG patients who had been genotyped for OPA1 variations, and who had...
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