Differential effects of <I>n</I>-3 and <I>n</I>-6 polyunsaturated fatty acids on <I>BRCA1</I> and <I>BRCA2</I> gene expression in breast cell lines

Abstract excerpt

Current evidence strongly supports a role for the breast tumour suppressor genes, BRCA1 and BRCA2, in both normal development and carcinogenesis. In vitro observations reported that BRCA1 and BRCA2 are expressed in a cell cycle-dependent manner. Interestingly, differences in the actions of n-3 and n-6 polyunsaturated fatty acids have been observed: while the n-3 polyunsaturated fatty acids have been described to...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to BRCA gene mutations in cancer
• Share to Genetic factors in colorectal cancer
• Share to Nutrition, Genetics, and Disease