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Article

Familial frontotemporal dementia associated with a novel presenilin-1 mutation.

Dementia and geriatric cognitive disorders - 1 Jan 2002

Tang-Wai D, Lewis P, Boeve Bradley, Hutton M, Golde T, Baker M, Hardy J, Michels V, Ivnik R, Jack C, Petersen R

Abstract excerpt

We report a kindred with three cases of dementia. The proband presented with forgetfulness and personality changes at age 56, followed shortly thereafter by behavioral dyscontrol, hyperphagia, hypersexuality, delusions, illusions, disinhibition and double incontinence. Neuroimaging studies were consistent with frontotemporal dementia (FTD). In one allele, an arginine insertion at codon 352 in the presenilin 1...

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Source

Identifiers

PMID: 12053127
DOI: 10.1159/000058328

Genes

PSEN1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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