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Psychiatric Disorders in Alzheimer Disease With the Presenilin-1 L226F Mutation.

Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology - 1 Dec 2020

Bartesaghi Francesca, Rosci Chiara Emilia, Rassiga Cecilia, Barbieri Valentina, Gambini Orsola, Floro Stefano, D'Arrigo Andrea Maria, Del Sole Angelo, Scarpini Elio Angelo, Galimberti Daniela, Priori Alberto

Abstract excerpt

The presenilin-1 (PSEN1) L226F mutation has been linked to very early onset of prominent behavioral and psychiatric disturbances followed by cognitive decline within a few years. We report a novel case of early-onset Alzheimer disease that was originally diagnosed as psychotic depression in a patient with this gene mutation. We also compare our patient's clinical data to those of other cases of this mutation that...

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PMID: 33264156
DOI: 10.1097/WNN.0000000000000249

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