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Article

The Friedreich's ataxia protein frataxin modulates DNA base excision repair in prokaryotes and mammals.

The Biochemical journal - 15 Nov 2010

Thierbach René, Drewes Gunnar, Fusser Markus, Voigt Anja, Kuhlow Doreen, Blume Urte, Schulz Tim J, Reiche Carina, Glatt Hansruedi, Epe Bernd, Steinberg Pablo, Ristow Michael

Abstract excerpt

DNA-repair mechanisms enable cells to maintain their genetic information by protecting it from mutations that may cause malignant growth. Recent evidence suggests that specific DNA-repair enzymes contain ISCs (iron-sulfur clusters). The nuclearencoded protein frataxin is essential for the mitochondrial biosynthesis of ISCs. Frataxin deficiency causes a neurodegenerative disorder named Friedreich's ataxia in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20819074
DOI: 10.1042/BJ20101116
PMCID: PMC2976068

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The Friedreich's ataxia protein frataxin modulates DNA base excision repair in prokaryotes and mammals.PMID 20819074Read ↗

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