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Article

Hyperphenylalaninemia and impaired glucose tolerance in mice lacking the bifunctional DCoH gene.

The Journal of biological chemistry - 9 Aug 2002

Bayle J Henri, Randazzo Filippo, Johnen Georg, Kaufman Seymour, Nagy Andras, Rossant Janet, Crabtree Gerald R

Abstract excerpt

The bifunctional protein DCoH (Dimerizing Cofactor for HNF1) acts as an enzyme in intermediary metabolism and as a binding partner of the HNF1 family of transcriptional activators. HNF1 proteins direct the expression of a variety of genes in the liver, kidney, pancreas, and gut and are critical to the regulation of glucose homeostasis. Mutations of the HNF1alpha gene underlie maturity onset diabetes of the young...

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PMID: 12011081
DOI: 10.1074/jbc.M201983200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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