Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CD44 variant-specific antibodies trigger hemopoiesis by selective release of cytokines from bone marrow macrophages.

Blood - 1 Jun 2002

Khaldoyanidi Sophia, Karakhanova Svetlana, Sleeman Jonathan, Herrlich Peter, Ponta Helmut

Abstract excerpt

Hemopoiesis is regulated by the complex interplay between the bone marrow microenvironment and hemopoietic stem cells and progenitors. The local production of cytokines plays a critical role in this process. Using long-term bone marrow cultures, we show here that monoclonal antibodies directed against the CD44 v4 and CD44 v6 epitopes stimulate myelopoiesis (CD44 v4 and CD44 v6) and lymphopoiesis (CD44 v6). In the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies
Share to Antibody Specificity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bone Marrow Cells

Share to Colony-Forming Units Assay

Share to Granulocyte-Macrophage Colony-Stimulating Factor

Share to Hematopoiesis

Share to Hyaluronan Receptors

Share to Mice, Inbred DBA

Source

Identifiers

PMID: 12010794
DOI: 10.1182/blood.v99.11.3955

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CD44 variant-specific antibodies trigger hemopoiesis by selective release of cytokines from bone marrow macrophages.PMID 12010794Read ↗

IL-6 supports the generation of human long-lived plasma cells in combination with either APRIL or stromal cell-soluble factorsSemantic proximity Read ↗

CD44v6 cell surface expression is a common feature of macrophages and macrophage-like cells - implication for a natural macrophage extravasation mechanism mimicked by tumor cells.Semantic proximity Read ↗

BAFF selectively enhances the survival of plasmablasts generated from human memory B cellsSemantic proximity Read ↗

Cytokines and hematopoietic stem cell mobilization.Semantic proximity Read ↗

CD6 monoclonal antibodies differ in epitope, kinetics and mechanism of action.Semantic proximity Read ↗

Characterization of the five novel Ly‐6 superfamily members encoded in the MHC, and detection of cells expressing their potential ligandsSemantic proximity Read ↗

Intracellular role of IL-6 in mesenchymal stromal cell immunosuppression and proliferationSemantic proximity Read ↗

Interferon-producing cells develop from murine CD31(high)/Ly6C(-) marrow progenitors.Semantic proximity Read ↗

The myeloid 7/4-antigen defines recently generated inflammatory macrophages and is synonymous with Ly-6B.Semantic proximity Read ↗

Ly-6 superfamily members Ly-6A/E, Ly-6C, and Ly-6I recognize two potential ligands expressed by B lymphocytes.Semantic proximity Read ↗

Interleukin-6 receptor-alpha signaling drives anti-RBC alloantibody production and T-follicular helper cell differentiation in a murine model of red blood cell alloimmunizationSemantic proximity Read ↗

CD44-mediated hyaluronan binding marks proliferating hematopoietic progenitor cells and promotes bone marrow engraftment.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.