Article
Human immunodeficiency virus nucleocapsid protein polymorphisms modulate the infectivity of RNA packaging mutants.
Virology - 15 Mar 2002
Krogstad Paul, Geng Yong-Zhi, Rey Osvaldo, Canon Jude, Ibarrondo F Javier, Ackerson Bradley, Patel Jignesh, Aldovini Anna
Abstract excerpt
The nucleocapsid protein (NC) of retroviruses is involved in viral RNA packaging and initiation of reverse transcription. NC also mediates interactions between Gag and actin filaments. We found that residues at the amino terminus of NC are involved in efficient actin binding. When alanine residue...
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