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Article

Human immunodeficiency virus nucleocapsid protein polymorphisms modulate the infectivity of RNA packaging mutants.

Virology - 15 Mar 2002

Krogstad Paul, Geng Yong-Zhi, Rey Osvaldo, Canon Jude, Ibarrondo F Javier, Ackerson Bradley, Patel Jignesh, Aldovini Anna

Abstract excerpt

The nucleocapsid protein (NC) of retroviruses is involved in viral RNA packaging and initiation of reverse transcription. NC also mediates interactions between Gag and actin filaments. We found that residues at the amino terminus of NC are involved in efficient actin binding. When alanine residues were substituted for the arginine and lysine at positions 10 and 11 of NC in HIV(NL4-3), these mutations decreased...

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Identifiers

PMID: 12009869
DOI: 10.1006/viro.2001.1319

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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