Article
Cytokine expression by attenuated intracellular bacteria regulates the immune response to infection: the Salmonella model.
Molecular immunology - 1 May 2002
al-Ramadi Basel K, Adeghate Ernest, Mustafa Nada, Ponery Abdul Samad, Fernandez-Cabezudo Maria J
Abstract excerpt
Attenuated Salmonella strains have shown excellent efficacy as mucosal vaccine delivery systems. In the present report, several recombinant strains of Salmonella enterica serovar Typhimurium, engineered to express defined murine cytokines, were used to study their potential immunoregulatory capacity in the mouse model of typhoid fever. Specifically, recombinant strains expressing IL-2 (known as GIDIL2) or...
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