G protein-coupled receptor kinases, beta-arrestin-2 and associated regulatory proteins in the human brain: postmortem changes, effect of age and subcellular distribution.

doi:10.1016/s0169-328x(02)00144-4

Article

G protein-coupled receptor kinases, beta-arrestin-2 and associated regulatory proteins in the human brain: postmortem changes, effect of age and subcellular distribution.

Brain research. Molecular brain research - 30 May 2002

Grange-Midroit Muriel, García-Sevilla Jesús A, Ferrer-Alcón Marcel, La Harpe Romano, Walzer Claude, Guimón José

Abstract excerpt

G protein-coupled receptor kinases (GRKs) and beta-arrestin-2 play a crucial role in the regulation of neurotransmitter receptors in brain. In this study, GRK2, GRK6, beta-arrestin-2 and associated regulatory proteins (Gbeta proteins and protein phosphatase (PP)-2A) were quantitated in human brains (immunodensity with specific antibodies) to assess for postmortem changes (pattern of protein degradation) and to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

G protein-coupled receptor kinases, beta-arrestin-2 and associated regulatory proteins in the human brain: postmortem changes, effect of age and subcellular distribution.

Abstract excerpt

Topics

Related research