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Article

A perspective on sporadic inclusion-body myositis: the role of aging and inflammatory processes.

Neurology - 24 Jan 2006

Finch Caleb E

Abstract excerpt

Sporadic inclusion-body myositis (sIBM) is an age-related condition manifested after midlife. This review points out salient features of sIBM that are shared with normal aging in muscle and with inflammatory changes in vascular atheromas and senile plaques of Alzheimer disease (AD). The amyloid precursor protein (APP) and derived Abeta peptides are found in both AD and sIBM. Because transgenic expression of human...

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Source

Identifiers

PMID: 16432135
DOI: 10.1212/01.wnl.0000192259.34541.e4

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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