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Article

CYP2A6 gene deletion reduces oral cancer risk in betel quid chewers in Sri Lanka.

Carcinogenesis - 1 Apr 2002

Topcu Zeki, Chiba Itsuo, Fujieda Masaki, Shibata Toshiyuki, Ariyoshi Noritaka, Yamazaki Hiroshi, Sevgican Figen, Muthumala Malsantha, Kobayashi Hiroshi, Kamataki Tetsuya

Abstract excerpt

We investigated the relationship between inter-individual difference in CYP2A6 genotype and susceptibility to oral cancer among habitual betel quid chewers in a Sri Lanka population. A total of 286 subjects showing oral malignant or premalignant lesions and 135 control subjects with no lesions were analyzed. The frequency of homozygotes for CYP2A6*4C mutation, a gene deletion type of polymorphism, was...

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PMID: 11960911
DOI: 10.1093/carcin/23.4.595

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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