Article
Association between chromosome 1p and 19q loss and outcome in pediatric malignant gliomas: results from the CCG-945 cohort.
Pediatric neurosurgery - 1 Sept 2003
Pollack Ian F, Finkelstein Sydney D, Burnham Judith, Hamilton Ronald L, Yates Allan J, Holmes Emiko J, Boyett James M, Finlay Jonathan L
Abstract excerpt
BACKGROUND: Results of recent molecular studies on malignant gliomas in adults showed that deletions within the short arm of chromosome 1 and/or the long arm of chromosome 19 identified a prognostically favorable subgroup of tumors that often respond to conventional chemotherapy. To determine if this association applies to pediatric malignant gliomas, we examined the correlation between 1p and 19q deletions and...
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