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Article

Decision analysis of prophylactic surgery or screening for BRCA1 mutation carriers: a more prominent role for oophorectomy.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 15 Apr 2002

van Roosmalen Mariëlle S, Verhoef Lia C G, Stalmeier Peep F M, Hoogerbrugge Nicoline, van Daal Willem A J

Abstract excerpt

PURPOSE: BRCA1 mutation carriers have a high risk of developing breast and ovarian cancer. Carriers may opt for prophylactic surgery and screening. Recent data suggesting that prophylactic oophorectomy reduces breast cancer risk have been incorporated in a decision analysis. METHODS: A Markov model was developed to compare LE and QALE following four strategies: (1) prophylactic mastectomy and prophylactic...

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Source

Identifiers

PMID: 11956270
DOI: 10.1200/jco.2002.08.035

Genes

BRCA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Decision analysis of prophylactic surgery or screening for BRCA1 mutation carriers: a more prominent role for oophorectomy.PMID 11956270Read ↗

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