A Gene from the Locus of Enterocyte Effacement That Is Required for Enteropathogenic<i>Escherichia coli</i>To Increase Tight-Junction Permeability Encodes a Chaperone for EspF

Abstract excerpt

Disruption of the barrier properties of the enterocyte tight junction is believed to be important in the pathogenesis of diarrhea caused by enteropathogenic Escherichia coli (EPEC). This phenotype can be measured in vitro as the ability of EPEC to reduce transepithelial resistance (TER) across enterocyte monolayers and requires the products of the locus of enterocyte effacement (LEE) and, in particular, the type...

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