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The Locus of Enterocyte Effacement-Encoded Effector Proteins All Promote Enterohemorrhagic <i>Escherichia coli</i> Pathogenicity in Infant Rabbits

24 Feb 2005

Abstract excerpt

The genes encoding the enterohemorrhagic Escherichia coli (EHEC) type III secretion system (TTSS) and five effector proteins secreted by the TTSS are located on the locus of enterocyte effacement (LEE) pathogenicity island. Deletion of tir, which encodes one of these effector proteins, results in a profound reduction (approximately 10,000-fold) in EHEC colonization of the infant rabbit intestine, but the in vivo...

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PMID: 15731044
DOI: 10.1128/iai.73.3.1466-1474.2005

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