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Article

An inducible pathway for degradation of FLIP protein sensitizes tumor cells to TRAIL-induced apoptosis.

The Journal of biological chemistry - 21 Jun 2002

Kim Youngsoo, Suh Nanjoo, Sporn Michael, Reed John C

Abstract excerpt

TRAIL (Apo2 ligand) is a member of the tumor necrosis factor (TNF) family of cytokines that induces apoptosis. Because TRAIL preferentially kills tumor cells, sparing normal tissues, interest has emerged in applying this biological factor for cancer therapy in humans. However, not all tumors resp...

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Identifiers

PMID: 11940602
DOI: 10.1074/jbc.M202458200

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11940602-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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An inducible pathway for degradation of FLIP protein sensitizes tumor cells to TRAIL-induced apoptosis.PMID 11940602Read ↗

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Alternative splicing variants of c-FLIP transduce the differential signal through the Raf or TRAF2 in TNF-induced cell proliferation.Semantic proximity Read ↗

Characterization of the Human FLICE‐Inhibitory Protein Locus and Comparison of the Anti‐Apoptotic Activity of Four Different FLIP IsoformsSemantic proximity Read ↗

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