Pituitary Autoantibodies in Lymphocytic Hypophysitis Target Both γ- and a-Enolase – A Link with Pregnancy?

Abstract excerpt

The first target autoantigen to have been identified in lymphocytic hypophysitis is a 49 kDa protein, identified as alpha-enolase. Pituitary autoimmunity is strongly associated with pregnancy and we have shown that pituitary autoantibodies from patients with peripartum lymphocytic hypophysitis also recognise enolase in the placenta. Enolase exists in different forms as a number of isoenzymes, which are homo- or...

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