Article
New developments in high-throughput resequencing and variation detection using high density microarrays.
Human mutation - 1 Apr 2002
Warrington Janet A, Shah Nila A, Chen Xiyin, Janis Michael, Liu Chunmei, Kondapalli Sangeetha, Reyes Vivian, Savage Michael P, Zhang Zhaomei, Watts Richard, DeGuzman Maria, Berno Anthony, Snyder Jim, Baid Jyoti
Abstract excerpt
We developed a high-throughput method for resequencing for single nucleotide polymorphism (SNP) discovery using high-density microarrays. Over the two-year course of this study a number of improvements in sample preparation methods, hybridization assay, array handling, and analysis method were developed and implemented. DNA from 40 unrelated individuals of three different ethnic origins was amplified, labeled,...
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