Article
Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion.
Nature - 4 Apr 2002
Terada Naohiro, Hamazaki Takashi, Oka Masahiro, Hoki Masanori, Mastalerz Diana M, Nakano Yuka, Meyer Edwin M, Morel Laurence, Petersen Bryon E, Scott Edward W
Abstract excerpt
Recent studies have demonstrated that transplanted bone marrow cells can turn into unexpected lineages including myocytes, hepatocytes, neurons and many others. A potential problem, however, is that reports discussing such 'transdifferentiation' in vivo tend to conclude donor origin of transdifferentiated cells on the basis of the existence of donor-specific genes such as Y-chromosome markers. Here we demonstrate...
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