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Moderate G6PD deficiency increases mutation rates in the brain of mice.

Free radical biology & medicine - 1 Apr 2002

Felix Klaus, Rockwood Lynne D, Pretsch Walter, Nair Jagadeesan, Bartsch Helmut, Bornkamm Georg Wilhelm, Janz Siegfried

Abstract excerpt

Mice that harbored the x-ray-induced low efficiency allele of the major X-linked isozyme of glucose-6-phospate dehydrogenase (G6PD), Gpdx(a-m2Neu), and, in addition, harbored the transgenic shuttle vector for the determination of mutagenesis in vivo, pUR288, were employed to further our understanding of the interdependence of general metabolism, oxidative stress control, and somatic mutagenesis. The Gpdx(a-m2Neu)...

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PMID: 11909700
DOI: 10.1016/s0891-5849(02)00756-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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