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Article

Purine synthesis de novo and salvage in hypoxanthine phosphoribosyltransferase-deficient mice.

Enzyme - 1 Jan 1990

Allsop J, Watts R W

Abstract excerpt

Extreme degrees of hypoxanthine phosphoribosyltransferase (HPRT) deficiency in man are associated with gross sex-linked neurological dysfunction, gout and urinary stones (the Lesch-Nyhan or 'complete HPRT-deficiency' syndrome). The less severe degrees of enzyme deficiency (sex-linked recessive gout and/or urolithiasis or the 'partial HPRT-deficiency' syndrome) may be associated with minor neurological...

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Identifiers

PMID: 2095336
DOI: 10.1159/000468723

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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