Article
Purine synthesis de novo and salvage in hypoxanthine phosphoribosyltransferase-deficient mice.
Enzyme - 1 Jan 1990
Allsop J, Watts R W
Abstract excerpt
Extreme degrees of hypoxanthine phosphoribosyltransferase (HPRT) deficiency in man are associated with gross sex-linked neurological dysfunction, gout and urinary stones (the Lesch-Nyhan or 'complete HPRT-deficiency' syndrome). The less severe degrees of enzyme deficiency (sex-linked recessive go...
Topics
- Adenine Phosphoribosyltransferase
- Animals
- Brain
- Female
- Gonads
- Homozygote
- Hypoxanthine Phosphoribosyltransferase
- Kidney
- Lesch-Nyhan Syndrome
- Male
- Mice
- Mice, Mutant Strains
- Mutation
- Purines
- Spleen