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Article

Cold-induced enzyme inactivation: how does cooling lead to pyridoxal phosphate-aldimine bond cleavage in tryptophanase?

Biochimica et biophysica acta - 11 Feb 2002

Erez Tali, Gdalevsky Garik Ya, Hariharan Chithra, Pines Dina, Pines Ehud, Phillips Robert S, Cohen-Luria Rivka, Parola Abraham H

Abstract excerpt

The phenomenon of cold scission or cold lability, which entails a widespread variety of oligomeric enzymes, is still enigmatic. The effect of cooling on the activity and the quaternary structure of the pyridoxal 5'-phosphate (PLP)-dependent enzyme, tryptophanase (Tnase), was studied utilizing sin...

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PMID: 11904229
DOI: 10.1016/s0167-4838(01)00325-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11904229-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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